B-ALL and B cell lymphoma

CAR T-Cell Immunotherapy for CD19+CD22+ Recurrent/ Refractory Acute B Lymphocytic Leukemia (B-ALL) and B cell lymphoma

Phase I/II Clinical Trial

Patients with relapsed or refractory acute B Lymphocytic leukemia (B-ALL) and B cell lymphoma often develop resistance to chemotherapy. For this reason, the investigators are attempting to use T-cells obtained directly from the patient, which can be genetically modified to express a chimeric antigen receptor (CAR) to CD19+CD22, expressed on the surface of the cell in patients with CD19+CD22+ B-ALL and B cell lymphoma. The CAR enables the T-cell to recognize and kill the cell through the recognition of CD19+CD22, a protein expressed on the surface of the cell in patients with CD19+CD22+ leukemia and B cell lymphoma. This is a Phase I/II study designed to evaluate the safety and efficacy of chimeric antigen receptor T cell immunotherapy (CAR-T) in the treatment of CD19+CD22+ leukemia and B cell lymphoma.

Phase I/II Open Clinical Trial

Through both our partner hospitals in Beijing, we at Zand Medicine gained direct access to the clinical trial recruitment process.

Study Type: Interventional (Clinical Trial)
Estimated Enrollment: 100 participants
Intervention Model Description: Single Group Assignment
Masking: Open-label trial
Primary Purpose: Treatment

How to apply for the Acute B Lymphocytic Leukemia (B-ALL) and B cell lymphoma CAR-T trial?

Fill in the below form. Add a short description of your case history and of your current condition. Our case manager will contact you shortly and guide you through. Remember, the earlier you start your treatment, the higher your chances to achieve Complete Remission (CR)

Inclusion Criteria

(The results of the examination after patients admitted in the hospital are the main criteria for admission)
• Be diagnosed with a kind of Relapsed or Refractory CD19+CD22+ B-ALL and B cell lymphoma;
• ECOG score≤2;
• To be aged 1 to 70 years;
• More than a month’s lifetime from the consent signing date.

Exclusion Criteria

• Serious cardiac insufficiency, left ventricular ejection fraction＜50%
• Has a history of severe pulmonary function damaging;
• Merging other progressing malignant tumor;
• Merging uncontrolled infection;
• Merging the metabolic diseases (except diabetes);
• Merging severe autoimmune diseases or immunodeficiency disease;
• Patients with active hepatitis B or hepatitis C;
• Patients with HIV infection;
• Has a history of serious allergies on Biological products (including antibiotics);
• Has acute GvHD on allogeneic hematopoietic stem cell transplantation patients after stopping immunosuppressants a month;
• Pregnancy or lactation women;
• Any situation that would increase the dangerousness of subjects or disturb the outcome of the clinical study according to the researcher’s evaluation.
* The Criteria is finally evaluated by Investigators.

AVERAGE CAR-T COST OF TREATMENT: 90,000-110,000 USD

As part of our CAR-T treatment package, we provide:

• Online medical consultancies about the efficacy of CAR-T treatment for you
• CAR-T Cell Treatment in a leading, experienced medical center.
• Travel and accommodation arrangements (upon request)
• All airport and hospital transfers
• Multi-lingual support and local escort teams, also providing translations for your medical documentation.

Zand Medicine – Your guardian angels abroad

We know that traveling abroad to receive medical treatment can be a stressful and challenging experience.
We promise we can make it much smoother.
Our executive case manager assigned to you will take your case through hospital’s bureaucracies, get all your questions answered and assist you in any way possible to assure that you stay is as comfortable as possible.
Our local team will meet you as you arrive at the local airport, accompany you through your treatment and wave you farewell as you depart back home.

We will bridge all the medical, cultural and lingual gaps for you.

How to apply for CAR-T therapy?

Zand Medicine works with the top hospitals that shine in the field of CAR-T treatment.

=> Fill in the contact form. Add a short description of your case history and of your current condition.
Our case manager will contact you shortly and guide you through.
Remember, the earlier you start your treatment, the higher your chances to achieve Complete Remission (CR).

What’s next?

1. Contact us: fill the contact form, send an email or give us a call.

2. Send us your medical documents. We will translate and forward them to our experts.

3. We will send you the various possible treatment plans and prices, and help you select the best option for you.

4. If you’d like, we can help in organizing your flights and accommodation.

5. Our personal attendant will meet you at the arrivals gate and accompany you throughout the course of your treatment.

6. We will send the translated release documents and keep in touch with you even after you leave.

Always here for you,

Zand Medicine